{"id":11671,"date":"2023-01-27T07:11:00","date_gmt":"2023-01-27T04:11:00","guid":{"rendered":"https:\/\/spitaljudeteanmures.ro\/scjm2\/?p=11671"},"modified":"2024-05-30T07:14:55","modified_gmt":"2024-05-30T04:14:55","slug":"reverse-preventie-si-instrumente-de-management-pentru-reducerea-rezistentei-la-antibiotice-in-situatii-de-prevalenta-inalta","status":"publish","type":"post","link":"https:\/\/spitaljudeteanmures.ro\/scjm2\/reverse-preventie-si-instrumente-de-management-pentru-reducerea-rezistentei-la-antibiotice-in-situatii-de-prevalenta-inalta\/","title":{"rendered":"REVERSE – pREVen\u021bie \u0219i instrumente de management pentru rEducerea Rezisten\u021bei la antibiotice \u00een Situa\u021bii de prEvalen\u021b\u0103 \u00eenalt\u0103"},"content":{"rendered":"\t\t
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REVERSE<\/span> <\/span><\/h2>\t\t\t\t\t

pREVen\u021bie \u0219i instrumente de management pentru rEducerea Rezisten\u021bei la antibiotice \u00een Situa\u021bii de prEvalen\u021b\u0103 \u00eenalt\u0103<\/span><\/h2><\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\u00cempreun\u0103 cu alte 5 spitale din Rom\u00e2nia, sub coordonarea Universit\u0103\u021bii de Medicin\u0103 \u0219i Farmacie \u201cCarol Davila\u201d <\/em>din Bucure\u0219ti, Spitalul Clinic Jude\u021bean Mure\u0219<\/strong> este unul dintre beneficiarii proiectului \u201cREVERSE<\/strong> (pREVention and management tools for rEducing antibiotic Resistance in high prevalence Settings<\/em>)\u201d. Proiectul este finan\u021bat prin programul Horizon 2020, European Health and Digital Executive Agency<\/em>, contract de finan\u021bare nr. Grant Agreement<\/em> (GA) No: 965265<\/em>. REVERSE (pREVen\u021bie \u0219i instrumente de management pentru rEducerea Rezisten\u021bei la antibiotice \u00een Situa\u021bii de prEvalen\u021b\u0103 \u00eenalt\u0103), \u0219i a \u00eenceput s\u0103 se deruleze din iulie 2021, pentru o perioad\u0103 de 5 ani, av\u00e2nd un buget total de aproximativ 14 milioane de euro.<\/span><\/p>

Emergen\u021ba rezisten\u021bei la antibiotice a devenit o problem\u0103 serioas\u0103 la nivel global, \u00een plin\u0103 expansiune, datele p\u00e2n\u0103 \u00een 2050 nefiind deloc optimiste, unii autori estim\u00e2nd un num\u0103r de 10 milioane de decese\/an. Dezvoltarea \u0219i implementarea unor strategii eficiente de preven\u021bie \u0219i control reprezint\u0103 elemente cruciale \u00een combaterea acesteia.<\/span><\/p>

Proiectul urm\u0103re\u0219te reducerea infec\u021biilor asociate asisten\u021bei medicale cauzate de bacterii Gram-negative multirezistente, cum ar fi Enterobacteriacee,<\/em> Pseudomonas aeruginosa,<\/em> \u0219i Acinetobacter baumannii<\/em> rezistente la carbapeneme (CRE, CRPA respectiv CRAB).<\/span><\/p>

REVERSE \u00ee\u0219i propune s\u0103 pun\u0103 \u00een aplicare un program complex de interven\u021bii eficiente, \u00een etape, bazat pe dovezi \u0219tiin\u021bifice, pentru a \u00eembun\u0103t\u0103\u021bi capacitatea de testare microbiologic\u0103, prevenirea \u0219i controlul infec\u021biilor \u00een spitale \u0219i utilizarea judicioas\u0103 a antimicrobienelor.<\/span><\/p>

Pentru a atinge acest scop, REVERSE este sus\u021binut de un consor\u021biu puternic din lumea academic\u0103, organiza\u021bii de s\u0103n\u0103tate \u0219i guvernamentale, incluz\u00e2nd 12 parteneri din Grecia, Israel, Italia, Olanda, Rom\u00e2nia, Spania, Elve\u021bia \u0219i Marea Britanie \u0219i un total de 24 de spitale pentru pacien\u021bi cu boli acute din Grecia Italia, Rom\u00e2nia, Spania. Entitatea coordonatoare a REVERSE este Universitatea din Zurich (Elve\u021bia), cu Dr. Walter Zingg \u00een rolul de coordonator.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Printr-un studiu clinic cu putere statistic\u0103, REVERSE va r\u0103spunde \u00eentreb\u0103rilor legate de eficien\u021ba real\u0103 a programelor de preven\u021bie \u0219i control ale infec\u021biilor, \u00een combina\u021bie cu programe de utilizare judicioas\u0103 a antibioticelor \u0219i \u00eembun\u0103t\u0103\u021birea diagnosticului microbiologic.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Trei interven\u021bii vor fi oferite spitalelor situate \u00een zone din Europa cu prevalen\u021b\u0103 ridicat\u0103 a bacililor Gram negativi multirezisten\u021bi la antibiotice, \u00een etape:<\/span><\/p>

1) un program de optimizare a diagnosticului microbiologic (MDS<\/strong>),<\/span><\/p>

2) un program de preven\u021bie \u0219i control al infec\u021biilor (IPC<\/strong>),<\/span><\/p>

3) un program de utilizare judicioas\u0103 a antibioticelor (ABS<\/strong>).<\/span><\/p>

La sf\u00e2r\u0219itul proiectului, spitalele participante pot deveni centre de referin\u021b\u0103 \u00een combaterea rezisten\u021bei la antimicrobiene, put\u00e2ndu-se crea astfel o re\u021bea na\u021bional\u0103 care s\u0103 continue acest demers.<\/span><\/p>

Studiul clinic REVERSE a \u00eenceput \u00een luna aprilie a anului 2022 cu perioade baseline<\/em> (de non-interven\u021bie) de 6, 9, 12 sau 15 luni, \u00een func\u021bie de o randomizare ini\u021bial\u0103 a spitalelor. Dup\u0103 aceste perioade baseline<\/em>, c\u00e2te 6 spitale vor \u00eencepe etapizat interven\u021biile, \u00eentotdeauna \u00een aceea\u0219i secven\u021b\u0103 (MDS, IPC, ABS).<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Desf\u0103\u0219urarea studiului se va realiza sub coordonarea unor grupuri de lucru (work packages, WP<\/em>), cu obiective at\u00e2t \u0219tiin\u021bifice (\u00een etapele de baseline \u0219i interven\u021bie MDS, IPC, ABS) c\u00e2t \u0219i administrative\/economice.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Grupul de lucru num\u0103rul 1 (WP-1): Studiile de spital<\/strong>\u00a0\u00a0\u00a0\u00a0 <\/strong><\/span><\/p>

Grupul de lucru num\u0103rul 1 se ocup\u0103 de organizarea \u0219i managementul p\u0103r\u021bii principale a proiectului REVERSE, un studiu clinic multicentric, de tip randomizare pe grupuri, secven\u021bial\u0103, privind eficacitatea optimiz\u0103rii diagnosticului microbiologic, preven\u021bia \u0219i controlul infec\u021biilor \u0219i utilizarea judicioas\u0103 a antibioticelor. Studiul clinic \u00een REVERSE a \u00eenceput cu o \u0219edin\u021b\u0103 a consor\u021biului REVERSE \u00eempreun\u0103 cu cele 24 de spitale participante, \u00een data de 23 februarie 2022 \u0219i cu colectarea datelor de supraveghere a infec\u021biilor asociate \u00eengrijirilor medicale \u00eencep\u00e2nd cu 1aprilie 2022.<\/span><\/p>

Grupul de lucru num\u0103rul 2 (WP-2): Program de optimizare a diagnosticului microbiologic (MDS)<\/strong>\u00a0\u00a0\u00a0\u00a0 <\/strong>\u00a0<\/strong><\/span><\/p>

Grupul de lucru num\u0103rul 2 (WP-2) se ocup\u0103 de interven\u021bia referitoare la diagnosticul microbiologic a celor 24 de spitale din Grecia, Italia, Rom\u00e2nia \u0219i Spania. Obiectivele principale sunt \u00eembun\u0103t\u0103\u021birea diagnosticelor microbiologice la nivel local pentru spitalele participante, pentru detec\u021bia CRE, CRPA \u0219i CRAB \u0219i determinarea prevalen\u021bei organismelor rezistente la carbapeneme precum \u0219i rela\u021bia clonal\u0103 dintre acestea. Prima interven\u021bie a proiectului REVERSE (MDS) a \u00eenceput \u00een luna octombrie 2022 cu primele 6 spitale. Pe parcursul proiectului urmeaz\u0103 s\u0103 fie dezvoltat un instrument de verificare \u00een vederea identific\u0103rii capacit\u0103\u021bii de testare microbiologic\u0103, a\u0219a \u00eenc\u00e2t s\u0103 se poat\u0103 face sugestii pentru m\u0103suri de \u00eembun\u0103t\u0103\u021bire a acesteia. Un sistem de control al calit\u0103\u021bii a fost stabilit de REVERSE prin trimiterea de tulpini c\u0103tre spitalele participante \u0219i o anchet\u0103 asupra prevalen\u021bei coloniz\u0103rii cu microorganisme rezistente la carbapeneme se va desf\u0103\u0219ura \u00een trei momente de-a lungul perioadei de desf\u0103\u0219urare a proiectului, \u00eenainte de interven\u021biile IPC \u0219i ABS \u0219i la finalul ABS \u00eencep\u00e2nd din martie 2023 la primele spitale randomizate.<\/span><\/p>

Grupul de lucru num\u0103rul 3 (WP-3): Programul de preven\u021bie \u0219i control a infec\u021biilor (IPC)\u00a0\u00a0\u00a0\u00a0 <\/strong><\/span><\/p>

Se ocup\u0103 cu Programul de Preven\u021bie \u0219i Control a Infec\u021biilor (IPC) \u00een cele 24 de spitale REVERSE din Grecia, Italia, Rom\u00e2nia \u0219i Spania. Principalele obiective ale pachetului 3 de lucru sunt de a stabili rezultatele unui program IPC pentru \u00eembun\u0103t\u0103\u021birea m\u0103surilor de control \u0219i preven\u021bie \u00een vederea sc\u0103derii inciden\u021bei infec\u021biilor asociate \u00eengrijirilor medicale cu CRE, CRPA \u0219i CRAB precum \u0219i a prevalen\u021bei CRE. \u00cen acest pachet de lucru, se vor dezvolta, implementa \u0219i evalua un set de m\u0103suri \u0219i instrumente de IPC pentru a controla organismele multidrog rezistente \u0219i de a stabili efectul acestor m\u0103suri asupra inciden\u021bei infec\u021biilor asociate \u00eengrijirilor medicale cu aceste microorganisme.<\/span><\/p>

Grupul de lucru num\u0103rul 4 (WP-4): Utilizarea judicioas\u0103 a antibioticelor (ABS)\u00a0\u00a0 \u00a0\u00a0<\/strong><\/span><\/p>

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Coordoneaz\u0103 programul de utilizare judicioas\u0103 a antibioticelor (ABS) \u00een cele 24 de spitale din cadrul proiectului REVERSE, c\u00e2te 6 spitale din fiecare \u021bar\u0103, Grecia, Italia, Rom\u00e2nia \u0219i Spania. Principalele sale obiective sunt de a reduce cantitatea de antibiotice utilizate \u0219i de a cre\u0219te calitatea utiliz\u0103rii, cu impact minim asupra apari\u021biei multi-rezisten\u021bei la antibiotice. \u00cen cadrul fiec\u0103rui spital vor fi identifica\u021bi membri pentru formarea unei echipe de ABS, ulterior vor fi organizate workshop-uri pentru instruirea acestei echipei. Din cele 24 de spitale jum\u0103tate vor avea interven\u021bii de baz\u0103, jum\u0103tate vor avea interven\u021bii avansate.<\/span><\/p>

\u00a0<\/strong><\/span>Echipa UMFCD a proiectului REVERSE<\/strong>\u00a0\u00a0\u00a0\u00a0<\/span><\/p>

  • Dr. Adriana Hristea – director<\/span><\/li>
  • \u0218ef de lucr\u0103ri Dr. Valeriu Gheorghi\u021b\u0103<\/span><\/li>
  • Doctorand Codru\u021ba-Georgiana Carp<\/span><\/li>
  • Doctorand Cristian-Mihail Niculae<\/span><\/li>
  • Doctorand Dr. Br\u00e2ndu\u0219a Bitel<\/span><\/li><\/ul>

    Echipa Spitalului Clinic Jude\u021bean Mure\u0219<\/strong><\/span><\/p>

    • Dr. Anca Meda V\u0103sie\u0219iu – investigator princial<\/span><\/li>
    • Mihai Negrea<\/span><\/li>
    • Teodora Cighir<\/span><\/li>
    • Asistent Adnana Stratu<\/span><\/li><\/ul>

      \u00a0<\/strong><\/span>Spitalele participante din Rom\u00e2nia \u00een proiectul<\/strong> REVERSE<\/strong><\/span><\/p>

      • Spitalul Universitar de Urgen\u021b\u0103 Militar Central Dr. Carol Davila<\/em>, Bucure\u0219ti;<\/span><\/li>
      • Spitalul Universitar de Urgen\u021b\u0103 Bucure\u0219ti (SUUB);<\/span><\/li>
      • Spitalul Clinic Municipal de Urgen\u021b\u0103 Timi\u0219oara;<\/span><\/li>
      • Spitalul Clinic Jude\u021bean Mure\u0219;<\/span><\/li>
      • Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 Sibiu;<\/span><\/li>
      • Institutul Clinic Fundeni;<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

        REVERSE pREVen\u021bie \u0219i instrumente de management pentru rEducerea Rezisten\u021bei la antibiotice \u00een Situa\u021bii de prEvalen\u021b\u0103 \u00eenalt\u0103 \u00cempreun\u0103 cu alte 5 spitale din Rom\u00e2nia, sub coordonarea Universit\u0103\u021bii de Medicin\u0103 \u0219i Farmacie<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-11671","post","type-post","status-publish","format-standard","hentry","category-proiecte"],"_links":{"self":[{"href":"https:\/\/spitaljudeteanmures.ro\/scjm2\/wp-json\/wp\/v2\/posts\/11671","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spitaljudeteanmures.ro\/scjm2\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spitaljudeteanmures.ro\/scjm2\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spitaljudeteanmures.ro\/scjm2\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/spitaljudeteanmures.ro\/scjm2\/wp-json\/wp\/v2\/comments?post=11671"}],"version-history":[{"count":0,"href":"https:\/\/spitaljudeteanmures.ro\/scjm2\/wp-json\/wp\/v2\/posts\/11671\/revisions"}],"wp:attachment":[{"href":"https:\/\/spitaljudeteanmures.ro\/scjm2\/wp-json\/wp\/v2\/media?parent=11671"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spitaljudeteanmures.ro\/scjm2\/wp-json\/wp\/v2\/categories?post=11671"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spitaljudeteanmures.ro\/scjm2\/wp-json\/wp\/v2\/tags?post=11671"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}